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• Intracortical MPH amplified cortical mobile excitability in rats, an impact which was lost next catecholamine depletion and was mediated by means of stimulation of α2 adrenergic receptors although not D1 receptors• AMP enhanced the mobile reaction of cortical and hippocampal neurons to CHPG (an mGluR form 5 agonist) in rats• AMP diminished